5. - Chronic Inflammation
Inflammation is a clever defense mechanism
mounted by your body's immune system in response damage. It is not a sign of weakness, it is a immune
repair mechanism designed to get your body back in top shape fast. Inflammation helps your body repel
intruders such as dirt, toxins or germs before they have a chance to create real health
problems. Research has shown that when inflammation
is out control it can seriously affect your health. For example, if you cut or burn your body or develop a bacterial or
viral infection, an inflammatory response will be mounted. Your body's defences are already hard at work
long before you notice the signs of inflammation - redness, heat and tenderness around the area
affected.
What you don't see is what is occurring inside your body - a
literal army of infection-fighting immune cells called macrophages, natural killer cells and T cells which
are busy mounting their response and engulfing and destroying germs and other cellular debris that shouldn't be
there.
Chronic inflammation that can't
switch off
Inflammation is a normal response of the body and a necessary
mechanism to keep us alive, and in short bursts it is life saving. The problem arises when this inflammatory
mechanism becomes chronic and is being negatively affected and mediated by a person being overweight, ageing,
physical inactivity, poor hygiene, low-grade infection (like poor dental hygiene, for example) and stress.
These are all triggers which can potentially create a low-grade continual inflammatory response by
your immune system.
Research has found that these inflammatory chemicals can assist
in the production of plaque in the artery walls. Unfortunately, as these plaque deposits form, these
inflammatory chemicals from your immune system can also help to rupture plaque, spewing tiny pieces of plaque
into your bloodstream and encouraging the formation of blood clots that can easily block a tiny artery in your
heart causing the death of that part of the heart muscle. When advanced, inflammation can lead double and even
quadruple your risk of a heart attack.
Researchers have long known chronic low-grade inflammation plays
a key role in the development of conditions such as asthma, rheumatoid arthritis, multiple sclerosis and
inflammatory bowel disease such as ulcerative colitis. Research is currently underway right now by the British
Heart Foundation to establish the precise mechanism that triggers the body's inflammatory
response.
Signs and symptoms of
chronic inflammation
- Tiredness
- Body aches and pains
- Congestion
- Frequent infections
- Diarrhea
- Dry eyes
- Indigestion
- Shortness of breath
- Skin outbreaks
- Swelling
- Stiffness
- Weight gain
- Obesity
The most common and deadly result of chronic inflammation
however is cardiovascular disease and some cancers.
CRP - one of your
best inflammatory markers
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C-reactive protein (CRP) is an immune-system chemical made by your liver in response to
inflammation occurring anywhere in your body. In Australia and NZ, CRP is being increasingly found
to be a useful way of predicting a person's risk of having a heart attack or other heart problem,
but unfortunately it is not yet a mainstream part of medicine. Read more on the Best Blood Tests page on this website.
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People who exercise
regularly have much lower blood levels of
CRP.
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Experts are now saying that a CRP test is possibly the best
way to predict your risk as it is seen as one of the best inflammatory predictors, and when it is combined with a person's LDL in particular, but also with HDL, Triglycerides,
Homocysteine, Lipoprotein (a) and other advanced markers offers possibly
the highest predictive determination of your full cardiovascular disease risk.
One theory is that while LDL lets you know how much plaque is
affecting your arteries, CRP tells you how likely that plaque is going to burst and become liberated in your
bloodstream, causing a dangerous clot to form.
Inflammatory triggers
What are some of the main reasons
and triggers which can make your body's immune system turn on you like this? It is interesting to note that
your smoke alarm will go on with a loud noise in your home if you smoke near it, just like the inflammation
mechanism will go off in your body if you smoke yourself!
Some of the most common reasons for
chronic low-grade inflammation are cigarette smoking, tummy fat, excess alcohol or food consumption, eating the
wrong foods (deep fried for example), lack of exercise or inactivity (the "sitting" disease) and daily stress.
Another source is being infected with agents like herpes, chlamydia and a common digestive bug called Helicobacter
pylori, which affects the stomach and upper digestive tract in up to 20 percent of Australians and New
Zealanders.
Other possible inflammatory
triggers are diabetes which is poorly controlled, high blood pressure, and high cholesterol (LDL)
levels. Your inflammatory immune mechanism is always on red alert, and even ready to switch on with minor
infections such as gum or tooth disease and urinary tract or skin infections. If these infections remain for some
time, then inflammation will remain also. This is why it is so important to fix up any problem areas in your body,
such as a continual dental or urinary problem issue before it can cause real problems further afield in your body.
A "stitch in time saves nine" literally!
Chronic low-grade inflammation - Common infections such
as bronchitis, herpes, chlamydia, continual sinus, gum or tooth infections and other lesser known bugs like
Helicobacter pylori (responsible for nearly all tummy ulcers) will stimulate and provoke your immune system
to stimulate the production of inflammatory mediators. Many people live continually with one small infection
or another. Heart researchers even discovered that just by giving a person long term low-grade antibiotics to
curb such infections they could slash the average person's heart risk!
The "sitting
disease" - Inactivity is a prime trigger for chronic low grade inflammation. Exercise helps to
increase HDL (good cholesterol) as well as reduce the levels of CRP (C-reactive protein) in your blood stream. And
high blood concentrations of CRP is very predictive of an early mortality of heart
disease.
Anxiety, worry and
stress - More and more
evidence suggests a relationship between the risk of cardiovascular disease and stress. Stress factors
include job strain, marital problems, financial worries/job stress, mortgage stress, bankruptcy, prison
term, social isolation and personality traits such as impatience, anger, irritability or being a
Type A personality. Acute and chronic stress may additionally affect other risk factors and
behaviors, such as high blood pressure and cholesterol levels, smoking, physical inactivity and
overeating.
Eating the wrong
fats - "Good" fats are found in nuts like walnuts and seeds, flaxseed oil, oily fish and fish
oil Omega 3 capsules. Healthy fats form the building block for inflammatory fighting immune components called
"eicosanoids". One of the key good fats is Omega3, and there is now more than ample research to validate taking one
or two fish oil capsules every day.
Take away foods -
A high fat, sugar and salt laden diet is one sure fire way to develop heart disease sooner rather than later due to
the damaging inflammatory effect on the vascular function. Fast foods high in saturated fats like deep fried fish
and chips or fatty meat pies will cause the bloodstream to have a sustained level of harmful fats for at least
three hours after eating. This condition is called "post-prandial (eating) hyperlipidemia". By eating fast foods
regularly you will be ensuring that you be keeping inflammation occurring indefinitely.
Abdominal or central
fat - Fat cells are seen by some researchers as "hormone pumps", as they have been found to secrete
inflammatory proteins into the bloodstream called cytokines which are directly responsible for
inflammation.
Oxidised
LDLs - Very dangerous indeed! - Oxidised LDLs occur when the "bad" (LDL) cholesterol reacts with tiny
molecules called free radicals (caused by smoking, toxins, liver detoxification, alcohol, chemicals, etc) in your
bloodstream. This in turn allows the LDL particles to become more easily incorporated into artery walls where they
set off an inflammatory response that helps produce plaque. Once inside the artery walls, cholesterol fatty acids
combine in the plaque with the oxidised LDL along with other immune system cells. An inflammatory response then
causes a de-stabilisation of the fibrous covering that normally keeps the plaque out of the bloodstream. These "hot
plaques" are often the ones most likely to rupture and flood the bloodstream with immune substances that prompt
fast blood clotting - that ultimately lead to massive heart attacks or significant
strokes.
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Key things
you need
to know
about Chronic Inflammation
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How inflammation
happens- Chronic, low-grade inflammation is bad for the heart and circulation as well as for
your health in general. If there is a low grade chronic inflammatory condition present, you will have a
continual production of compounds released into your bloodstream, encouraging a continual production of tiny
blood clots, leading to a stroke or a heart attack.
How inflammation takes
place:
- Inflammatory immune particles discover
LDL in artery walls.
- Immune scavenger cells called
macrophages are sent to eradicate the unwanted cholesterol.
- Foam cells are produced, which are the
by-products (oxidised LDL) that form the basis of plaque.
- Plaque grows and develops a hard
fibrous cap.
- Inflammatory immune compounds weaken
the cap and weaken the protective lid covering the plaque.
- The cap ruptures releasing the fatty
contents into the bloodstream.
- The immune system attacks the liberated
fatty deposits encouraging blood to clot.
Standard medical care for
inflammation- There are presently no pharmaceutical drugs to counter chronic low grade inflammation in the body.
Some doctors may prescribe Statin (cholesterol lowering) drugs or low-dose aspirin for these conditions. Other
doctors are even considering placing patients on long-term low grade antibiotics for people who present with
persistent, low grade infections. The problem here is that long term antibiotic therapy will undermine the
digestive and immune systems, causing side-effects and long term dysfunction leading to yet more
disease.
Predictive value in
medicine - It has only been a few
years since the link between long term inflammation and heart disease has emerged. We now know the even patients
with near normal cholesterol levels yet presenting with chronic low grade inflammation can go on to have heart
attacks. Doctors would do well to more fully establish their patient's risks, particularly those with a strong
family history of heart disease.
Detecting
inflammation - Conventional doctors
may well one day use the CRP (C-reactive protein) test more routinely to diagnose patients at risk. Most all
integrative or functional medicine practitioners (doctors who successfully combine Western and natural medicine in
their clinics) already perform this test. Enlightened naturopaths with more science based training also check a
patient's CRP levels.
The possibility of
self-treatment - High for
most people with chronic low-grade inflammation, but you will need to look after your whole body. Ensure you
have regular check-ups with your dentist and eradicate any gum infections or dental caries sooner rather than
later. Treat any infections promptly, for example ensure you don't have any stomach bacteria which can cause
Helicobacter pylori (have your blood and stool tested if in doubt). Treat herpes promptly. Lose excess tummy fat
and make sure you regularly take Omega 3 fish oils which are anti-inflammatory.
Heart
Drops can assist and support your heart and circulation, even in those with and elevated CRP, and when
your inflammatory response begins to normalise due to your changes in diet and lifestyle and natural
treatment you can reduce and eventually stop the Heart Drops. Ensure you ask your doctor to check your
CRP levels, and get regular blood tests to determine your inflammatory response in your body.
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